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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Oridonin, Doxorubicin
Phytochemical Name Oridonin (PubChem CID: 5321010 )
Anticancer drug Name Doxorubicin (PubChem CID: 31703 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Decreasing Drug Toxicity
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The theory of cold and heat
Drug Name Doxorubicin
Adverse Reactions Nausea, vomiting, diarrhoea. This was inferred cold nature anticancer drug.
Recommendations Hot: Ligusticum chuam; Angelica sinensis; Zingiber officinale; Panax ginseng; Pogostemon cablin
Reference ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.　　ref_link
Combination Pair ID: 182
Ref_1
Pair Name Oridonin, Doxorubicin
Disease Info [ICD-11: 2C60] Breast cancer Investigative
Biological Phenomena Inhibition-->Angiogenesis
Gene Regulation Down-regulation Expression KDR hsa3791
In Vitro Model MDA-MB-231 Breast adenocarcinoma Homo sapiens (Human) CVCL_0062
In Vivo Model A breast tumor xenograft model was established via subcutaneous flank inoculation of BALB/c female nude mice with 1×10⁶ MDA-MB-231 cells in 100 μl PBS containing 50% Matrigel per mouse.
Result Our findings provide strong evidence that Ori may be highly promising in enhancing the efficacy of Dox and decreasing its adverse cardiotoxic effects, thus suggesting that Ori may serve as a potential adjunct therapy during Dox-based chemotherapy.
Combination Pair ID: 180
Ref_2
Pair Name Oridonin, Doxorubicin
Disease Info [ICD-11: 2B51] Osteosarcoma Investigative
Biological Phenomena Induction-->ROS generation
Gene Regulation Up-regulation Expression ROS1 hsa6098
In Vitro Model SaOS-2 Osteosarcoma Homo sapiens (Human) CVCL_0548
Result The combined use of oridonin and doxorubicin could help to reduce the clinical dosage of doxorubicin and its dangerous side effects.
03. Reference
No. Title Href
1 Oridonin synergistically enhances the anti-tumor efficacy of doxorubicin against aggressive breast cancer via pro-apoptotic and anti-angiogenic effects. Pharmacol Res. 2019 Aug;146:104313. doi: 10.1016/j.phrs.2019.104313. Click
2 Oridonin enhances antitumor effects of doxorubicin in human osteosarcoma cellsOridonin enhances antitumor effects of doxorubicin in human osteosarcoma cells. Pharmacol Rep. 2022 Feb;74(1):248-256. doi: 10.1007/s43440-021-00324-1. Click
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